منابع مشابه
Ras: structural details to guide direct targeting
These proteins are mutated in about 20% of all human cancers and are thus important targets for drug discovery [1]. Major efforts over the last 20 years have not yielded drugs, promoting the notion that Ras is undruggable [2]. Recent advances in the structural biology of Ras provide new venues to be explored. The crystal structure of Ras has been known for over 25 years. Structural rearrangemen...
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Protein folding is often difficult to characterize experimentally because of the transience of intermediate states, and the complexity of the protein-solvent system. Atomistic simulations, which could provide more detailed information, have had to employ highly simplified models or high temperatures, to cope with the long time scales of unfolding; direct simulation of folding is even more probl...
متن کاملStructural details of the OxyR peroxide-sensing mechanism.
OxyR, a bacterial peroxide sensor, is a LysR-type transcriptional regulator (LTTR) that regulates the transcription of defense genes in response to a low level of cellular H2O2. Consisting of an N-terminal DNA-binding domain (DBD) and a C-terminal regulatory domain (RD), OxyR senses H2O2 with conserved cysteine residues in the RD. However, the precise mechanism of OxyR is not yet known due to t...
متن کاملPores of Kohn.
The history of the investigations into interalveolar communications (pores of Kohn) shows that the question whether they exist and, if so, their nature has for approximately a century been contentious. The present electron microscopic study of the lungs of mice demonstrates that alveolar pores are normal structures, with edges composed of intact alveolar wall. A number of planes are demonstrate...
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ژورنال
عنوان ژورنال: Journal of Ultrastructure Research
سال: 1972
ISSN: 0022-5320
DOI: 10.1016/s0022-5320(72)80027-3